Ontology highlight
ABSTRACT:
SUBMITTER: Allard CAH
PROVIDER: S-EPMC5940308 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Allard Corey A H CAH Opalko Hannah E HE Liu Ko-Wei KW Medoh Uche U Moseley James B JB
The Journal of cell biology 20180307 5
Cell size control requires mechanisms that link cell growth with Cdk1 activity. In fission yeast, the protein kinase Cdr2 forms cortical nodes that include the Cdk1 inhibitor Wee1 along with the Wee1-inhibitory kinase Cdr1. We investigated how nodes inhibit Wee1 during cell growth. Biochemical fractionation revealed that Cdr2 nodes were megadalton structures enriched for activated Cdr2, which increases in level during interphase growth. In live-cell total internal reflection fluorescence microsc ...[more]