Induction of stemlike cells with fibrogenic properties by carbon nanotubes and its role in fibrogenesis.
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ABSTRACT:
SUBMITTER: Luanpitpong S
PROVIDER: S-EPMC4055043 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Induction of stemlike cells with fibrogenic properties by carbon nanotubes and its role in fibrogenesis.
Luanpitpong Sudjit S Wang Liying L Manke Amruta A Martin Karen H KH Ammer Amanda Gatesman AG Castranova Vincent V Yang Yong Y Rojansakul Yon Y
Nano letters 20140530 6
We developed a three-dimensional fibroblastic nodule model for fibrogenicity testing of nanomaterials and investigated the role of fibroblast stemlike cells (FSCs) in the fibrogenic process. We showed that carbon nanotubes (CNTs) induced fibroblastic nodule formation in primary human lung fibroblast cultures resembling the fibroblastic foci in clinical fibrosis and promoted FSCs that are highly fibrogenic and a potential driving force of fibrogenesis. This study provides a predictive 3D model an ...[more]
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