Pharmacometabolomics of statin response.
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ABSTRACT:
SUBMITTER: Krauss RM
PROVIDER: S-EPMC4055080 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Pharmacometabolomics of statin response.
Krauss R M RM Zhu H H Kaddurah-Daouk R R
Clinical pharmacology and therapeutics 20130814 5
Statins reduce risk of cardiovascular disease (CVD) by decreasing plasma low-density lipoprotein (LDL) concentrations, as well as reducing inflammation and improving endothelial function. Despite their documented efficacy, there is considerable interindividual variation in effects of statins on CVD biomarkers. In the studies summarized here, we used complementary metabolomics platforms to define global effects of a statin (simvastatin) on metabolism and to identify markers indicative of mechanis ...[more]
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