The relationship between reward and punishment processing and the 5-HT1A receptor as shown by PET.

ABSTRACT:

Rationale

The serotonin (5-HT) system has been reported to be involved in decision-making. A key component of this neurotransmitter system is the 5-HT1A receptor, and research is beginning to show how this receptor can influence decision-making. However, this relationship has rarely been studied in humans.

Objectives

This study assessed whether individual variability in 5-HT1A availability correlates with decision-making in healthy volunteers.

Methods

We measured regional availability of the 5-HT1A receptor in the hippocampal complex and striatum using positron emission tomography and correlated this with performance on two decision-making tasks measuring sensitivity to probability, rewards and punishments and temporal discounting, respectively.

Results

No rela

SUBMITTER: Faulkner P 

PROVIDER: S-EPMC4057624 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature