Ontology highlight
ABSTRACT:
SUBMITTER: Mao XY
PROVIDER: S-EPMC4057698 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20140505 5
The present study was designed to probe the effects of Huperzine A (HupA) on diabetes-associated cognitive decline (DACD) using a streptozotocin (STZ)-injected rat model. Diabetic rats were treated with HupA (0.05 and 0.1 mg/kg) for seven weeks. Memory functions were evaluated by the water maze test. Nissl staining was selected for detecting neuronal loss. Protein and mRNA levels of brain-derived neurotrophic factor (BDNF) were analyzed by ELISA and real-time PCR, respectively. The activities of ...[more]