Ontology highlight
ABSTRACT:
SUBMITTER: Madhusudhan A
PROVIDER: S-EPMC4057728 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Madhusudhan Alle A Reddy Gangapuram Bhagavanth GB Venkatesham Maragoni M Veerabhadram Guttena G Kumar Dudde Anil DA Natarajan Sumathi S Yang Ming-Yeh MY Hu Anren A Singh Surya S SS
International journal of molecular sciences 20140509 5
Doxorubicin (DOX) was immobilized on gold nanoparticles (AuNPs) capped with carboxymethyl chitosan (CMC) for effective delivery to cancer cells. The carboxylic group of carboxymethyl chitosan interacts with the amino group of the doxorubicin (DOX) forming stable, non-covalent interactions on the surface of AuNPs. The carboxylic group ionizes at acidic pH, thereby releasing the drug effectively at acidic pH suitable to target cancer cells. The DOX loaded gold nanoparticles were effectively absorb ...[more]