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Efficient pH dependent drug delivery to target cancer cells by gold nanoparticles capped with carboxymethyl chitosan.


ABSTRACT: Doxorubicin (DOX) was immobilized on gold nanoparticles (AuNPs) capped with carboxymethyl chitosan (CMC) for effective delivery to cancer cells. The carboxylic group of carboxymethyl chitosan interacts with the amino group of the doxorubicin (DOX) forming stable, non-covalent interactions on the surface of AuNPs. The carboxylic group ionizes at acidic pH, thereby releasing the drug effectively at acidic pH suitable to target cancer cells. The DOX loaded gold nanoparticles were effectively absorbed by cervical cancer cells compared to free DOX and their uptake was further increased at acidic conditions induced by nigericin, an ionophore that causes intracellular acidification. These results suggest that DOX loaded AuNPs with pH-triggered drug releasing properties is a novel nanotheraputic approach to overcome drug resistance in cancer.

SUBMITTER: Madhusudhan A 

PROVIDER: S-EPMC4057728 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Efficient pH dependent drug delivery to target cancer cells by gold nanoparticles capped with carboxymethyl chitosan.

Madhusudhan Alle A   Reddy Gangapuram Bhagavanth GB   Venkatesham Maragoni M   Veerabhadram Guttena G   Kumar Dudde Anil DA   Natarajan Sumathi S   Yang Ming-Yeh MY   Hu Anren A   Singh Surya S SS  

International journal of molecular sciences 20140509 5


Doxorubicin (DOX) was immobilized on gold nanoparticles (AuNPs) capped with carboxymethyl chitosan (CMC) for effective delivery to cancer cells. The carboxylic group of carboxymethyl chitosan interacts with the amino group of the doxorubicin (DOX) forming stable, non-covalent interactions on the surface of AuNPs. The carboxylic group ionizes at acidic pH, thereby releasing the drug effectively at acidic pH suitable to target cancer cells. The DOX loaded gold nanoparticles were effectively absorb  ...[more]

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