Ontology highlight
ABSTRACT:
SUBMITTER: Shirazi AN
PROVIDER: S-EPMC6271229 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Shirazi Amir Nasrolahi AN Paquin Karissa L KL Howlett Niall G NG Mandal Dindyal D Parang Keykavous K
Molecules (Basel, Switzerland) 20140828 9
Previously, we have reported the synthesis of a homochiral l-cyclic peptide [WR]5 and its use for delivery of anti-HIV drugs and biomolecules. A physical mixture of HAuCl4 and the peptide generated peptide-capped gold nanoparticles. Here, [WR]5 and [WR]5-AuNPs were tested for their efficiency to deliver a small interfering RNA molecule (siRNA) in human cervix adenocarcinoma (HeLa) cells. Flow cytometry investigation revealed that the intracellular uptake of a fluorescence-labeled non-targeting s ...[more]