Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC4058033 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Liu Juan J Zhang Cen C Lin Meihua M Zhu Wei W Liang Yingjian Y Hong Xuehui X Zhao Yuhan Y Young Ken H KH Hu Wenwei W Feng Zhaohui Z
Oncotarget 20140501 9
The tumor suppressor p53 and its signaling pathway play a critical role in tumor prevention. As a direct p53 target gene, the role of glutaminase 2 (GLS2) in tumorigenesis is unclear. In this study, we found that GLS2 expression is significantly decreased in majority of human hepatocellular carcinoma (HCC). Restoration of GLS2 expression in HCC cells inhibits the anchorage-independent growth of cells and reduces the growth of HCC xenograft tumors. Interestingly, we found that GLS2 negatively reg ...[more]