Ontology highlight
ABSTRACT:
SUBMITTER: Shin JM
PROVIDER: S-EPMC3999113 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Shin Jung-Min JM Kim Mi Yoon MY Sohn Kyung-Cheol KC Jung So-Young SY Lee Hae-Eul HE Lim Jae Woo JW Kim Sooil S Lee Young-Ho YH Im Myung M Seo Young-Joon YJ Kim Chang Deok CD Lee Jeung-Hoon JH Lee Young Y Yoon Tae-Jin TJ
PloS one 20140424 4
Nrf2 plays a role in protection of cells against oxidative stress and xenobiotic damage by regulating cytoprotective genes. In this study, we investigated the effect of Nrf2 on melanogenesis in normal human melanocytes (NHMCs). When NHMCs were transduced with a recombinant adenovirus expressing Nrf2, melanin synthesis was significantly decreased. Consistent with this result, overexpression of Nrf2 decreased the expression of tyrosinase and tyrosinase-related protein 1. The inhibitory effect of N ...[more]