Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC5862290 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Wang Xuefeng X Zhang Zhenyu Z Morris Nathan N Cai Tianxi T Lee Seunggeun S Wang Chaolong C Yu Timothy W TW Walsh Christopher A CA Lin Xihong X
Briefings in bioinformatics 20171101 6
The objective of this article is to introduce valid and robust methods for the analysis of rare variants for family-based exome chips, whole-exome sequencing or whole-genome sequencing data. Family-based designs provide unique opportunities to detect genetic variants that complement studies of unrelated individuals. Currently, limited methods and software tools have been developed to assist family-based association studies with rare variants, especially for analyzing binary traits. In this artic ...[more]