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Induction of protective immune response against both PPRV and FMDV by a novel recombinant PPRV expressing FMDV VP1.

ABSTRACT: Peste des petits ruminants (PPR) and foot-and-mouth disease (FMD) are both highly contagious diseases of small domestic and wild ruminants caused by the PPR virus (PPRV) and the FMD virus (FMDV). In this study, a recombinant PPRV expressing the FMDV VP1 gene (rPPRV/VP1) was generated and FMDV VP1 expression did not impair replication of the recombinant virus in vitro and immunogenicity in inducing neutralizing antibody against PPR in goats. Vaccination with one dose of rPPRV/VP1 induced FMDV neutralizing antibody in goats and protected them from challenge with virulent FMDV. Our results suggest that the recombinant PPRV expressing the FMDV VP1 protein is a potential dual live vectored vaccine against PPRV and FMDV.

SUBMITTER: Yin C

PROVIDER: S-EPMC4059095 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Induction of protective immune response against both PPRV and FMDV by a novel recombinant PPRV expressing FMDV VP1.

Yin Chunsheng C Chen Weiye W Hu Qianqian Q Wen Zhiyuan Z Wang Xijun X Ge Jinying J Yin Qianqian Q Zhi Haibing H Xia Chun C Bu Zhigao Z

Veterinary research 20140604

Peste des petits ruminants (PPR) and foot-and-mouth disease (FMD) are both highly contagious diseases of small domestic and wild ruminants caused by the PPR virus (PPRV) and the FMD virus (FMDV). In this study, a recombinant PPRV expressing the FMDV VP1 gene (rPPRV/VP1) was generated and FMDV VP1 expression did not impair replication of the recombinant virus in vitro and immunogenicity in inducing neutralizing antibody against PPR in goats. Vaccination with one dose of rPPRV/VP1 induced FMDV neu ...[more]

PMID: 24898430

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