Ontology highlight
ABSTRACT:
SUBMITTER: Curto JM
PROVIDER: S-EPMC4059215 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20140514 11
Allylating agents were explored for the asymmetric synthesis of α-allyl-α-aryl α-amino acids by tandem N-alkylation/π-allylation. Cross-metathesis of the tandem product was developed to provide allylic diversity not afforded in the parent reaction; the synthesis of homotyrosine and homoglutamate analogues was completed. Cyclic α-amino acid derivatives could be accessed by ring-closing metathesis presenting a viable strategy to higher ring homologue of enantioenriched α-substituted proline. The e ...[more]