Ontology highlight
ABSTRACT:
SUBMITTER: Liu D
PROVIDER: S-EPMC7683563 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Nature communications 20201123 1
Chiral α-aryl glycines play a key role in the preparation of some bioactive products, however, their catalytic asymmetric synthesis is far from being satisfactory. Herein, we report an efficient nickel-catalyzed asymmetric hydrogenation of N-aryl imino esters, affording chiral α-aryl glycines in high yields and enantioselectivities (up to 98% ee). The hydrogenation can be conducted on a gram scale with a substrate/catalyst ratio of up to 2000. The obtained chiral N-p-methoxyphenyl α-aryl glycine ...[more]