Ontology highlight
ABSTRACT:
SUBMITTER: Deri MA
PROVIDER: S-EPMC4059252 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Deri Melissa A MA Ponnala Shashikanth S Zeglis Brian M BM Pohl Gabor G Dannenberg J J JJ Lewis Jason S JS Francesconi Lynn C LC
Journal of medicinal chemistry 20140519 11
Zirconium-89 is an effective radionuclide for antibody-based positron emission tomography (PET) imaging because its physical half-life (78.41 h) matches the biological half-life of IgG antibodies. Desferrioxamine (DFO) is currently the preferred chelator for (89)Zr(4+); however, accumulation of (89)Zr in the bones of mice suggests that (89)Zr(4+) is released from DFO in vivo. An improved chelator for (89)Zr(4+) could eliminate the release of osteophilic (89)Zr(4+) and lead to a safer PET tracer ...[more]