Ontology highlight
ABSTRACT:
SUBMITTER: Allott L
PROVIDER: S-EPMC6055981 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Allott L L Da Pieve C C Meyers J J Spinks T T Ciobota D M DM Kramer-Marek G G Smith G G
Chemical communications (Cambridge, England) 20170701 61
The future of <sup>89</sup>Zr-based immuno-PET is reliant upon the development of new chelators with improved stability compared to the currently used deferoxamine (DFO). Herein, we report the evaluation of the octadentate molecule DFO-HOPO (3) as a suitable chelator for <sup>89</sup>Zr and a more stable alternative to DFO. The molecule showed good potential for the future development of a DFO-HOPO-based bifunctional chelator (BFC) for the radiolabelling of biomolecules with <sup>89</sup>Zr. Thi ...[more]