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Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer.

ABSTRACT: A simple approach to enhancing the activity and stability of organophosphorus hydrolase (OPH) is developed based on interactions between the hydrophobic poly(propylene oxide) (PPO) block of amphiphilic Pluronics and the enzyme. This strategy provides an efficient route to new formulations for decontaminating organophosphate neurotoxins.

SUBMITTER: Kim M 

PROVIDER: S-EPMC4059822 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer.

Kim Minkyu M   Gkikas Manos M   Huang Aaron A   Kang Jeon Woong JW   Suthiwangcharoen Nisaraporn N   Nagarajan Ramanathan R   Olsen Bradley D BD  

Chemical communications (Cambridge, England) 20140221 40

A simple approach to enhancing the activity and stability of organophosphorus hydrolase (OPH) is developed based on interactions between the hydrophobic poly(propylene oxide) (PPO) block of amphiphilic Pluronics and the enzyme. This strategy provides an efficient route to new formulations for decontaminating organophosphate neurotoxins. ...[more]

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