Ontology highlight
ABSTRACT:
SUBMITTER: Ramalho EA
PROVIDER: S-EPMC4060371 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Ramalho Eduardo Avf EA Silva-Filho João Lq JL Cartaxo Marina Fs MF Cavalcanti Carmelita Bl CB Rêgo Moacyr Jbm MJ Oliveira Maria Bm MB Beltrão Eduardo Ic EI
Biological research 20140326
<h4>Background</h4>BRCA protein interacts with at least 13 different proteins that have been implicated with cancer susceptibility and loss of BRCA function is correlated to sensitivity to DNA crosslinking agents in preclinical models.<h4>Results</h4>BRCA2 methylation frequency was 44%, p53 Pro22 allele frequency was 32% and heterozygous frequency of Arg/Pro72 genotype was 60% which could be associated as risk factor for metastasis (p = 0.046 OR = 4.190). Regarding to polymorphism of codon 249 t ...[more]