Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study.
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ABSTRACT:
SUBMITTER: Abou Alaiwa MH
PROVIDER: S-EPMC4060428 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
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Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study.
Abou Alaiwa Mahmoud H MH Beer Alison M AM Pezzulo Alejandro A AA Launspach Janice L JL Horan Rebecca A RA Stoltz David A DA Starner Timothy D TD Welsh Michael J MJ Zabner Joseph J
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20140111 4
<h4>Background</h4>Disrupted HCO3(-) transport and reduced airway surface liquid (ASL) pH in cystic fibrosis (CF) may initiate airway disease. We hypothesized that ASL pH is reduced in neonates with CF.<h4>Methods</h4>In neonates with and without CF, we measured pH of nasal ASL. We also measured nasal pH in older children and adults.<h4>Results</h4>In neonates with CF, nasal ASL (pH5.2 ± 0.3) was more acidic than in non-CF neonates (pH6.4 ± 0.2). In contrast, nasal pH of CF children and adults w ...[more]
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