Ontology highlight
ABSTRACT:
SUBMITTER: Riddell J
PROVIDER: S-EPMC4060823 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Riddell Jonah J Gazit Roi R Garrison Brian S BS Guo Guoji G Saadatpour Assieh A Mandal Pankaj K PK Ebina Wataru W Volchkov Pavel P Yuan Guo-Cheng GC Orkin Stuart H SH Rossi Derrick J DJ
Cell 20140401 3
Hematopoietic stem cells (HSCs) sustain blood formation throughout life and are the functional units of bone marrow transplantation. We show that transient expression of six transcription factors Run1t1, Hlf, Lmo2, Prdm5, Pbx1, and Zfp37 imparts multilineage transplantation potential onto otherwise committed lymphoid and myeloid progenitors and myeloid effector cells. Inclusion of Mycn and Meis1 and use of polycistronic viruses increase reprogramming efficacy. The reprogrammed cells, designated ...[more]