Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC3409465 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Kim Jongpil J Lengner Christopher J CJ Kirak Oktay O Hanna Jacob J Cassady John P JP Lodato Michael A MA Wu Su S Faddah Dina A DA Steine Eveline J EJ Gao Qing Q Fu Dongdong D Dawlaty Meelad M Jaenisch Rudolf R
Stem cells (Dayton, Ohio) 20110601 6
Pluripotent cells can be derived from different types of somatic cells by nuclear reprogramming through the ectopic expression of four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc. However, it is unclear whether postmitotic neurons are susceptible to direct reprogramming. Here, we show that postnatal cortical neurons, the vast majority of which are postmitotic, are amenable to epigenetic reprogramming. However, ectopic expression of the four canonical reprogramming factors is not suffici ...[more]