Ontology highlight
ABSTRACT:
SUBMITTER: Spencer J
PROVIDER: S-EPMC4063849 | biostudies-literature | 2014 Mar-Apr
REPOSITORIES: biostudies-literature
Spencer Janice J Leuzzi Rosanna R Buckley Anthony A Irvine June J Candlish Denise D Scarselli Maria M Douce Gillian R GR
Gut microbes 20140122 2
Clostridium difficile is a major cause of antibiotic associated diarrhea. Recently, we have shown that effective protection can be mediated in hamsters through the inclusion of specific recombinant fragments from toxin A and B in a systemically delivered vaccine. Interestingly while neutralizing antibodies to the binding domains of both toxin A and B are moderately protective, enhanced survival is observed when fragments from the glucosyltransferase region of toxin B replace those from the bindi ...[more]