Ontology highlight
ABSTRACT:
SUBMITTER: Chumbler NM
PROVIDER: S-EPMC4976693 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Chumbler Nicole M NM Rutherford Stacey A SA Zhang Zhifen Z Farrow Melissa A MA Lisher John P JP Farquhar Erik E Giedroc David P DP Spiller Benjamin W BW Melnyk Roman A RA Lacy D Borden DB
Nature microbiology 20160111
Clostridium difficile infection is the leading cause of hospital-acquired diarrhoea and pseudomembranous colitis. Disease is mediated by the actions of two toxins, TcdA and TcdB, which cause the diarrhoea, as well as inflammation and necrosis within the colon. The toxins are large (308 and 270 kDa, respectively), homologous (47% amino acid identity) glucosyltransferases that target small GTPases within the host. The multidomain toxins enter cells by receptor-mediated endocytosis and, upon exposu ...[more]