Ontology highlight
ABSTRACT:
SUBMITTER: Mugford JW
PROVIDER: S-EPMC4063926 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Mugford Joshua W JW Starmer Joshua J Williams Rex L RL Calabrese J Mauro JM Mieczkowski Piotr P Yee Della D Magnuson Terry T
Genetics 20140319 2
X chromosome inactivation (XCI) is an epigenetic process that almost completely inactivates one of two X chromosomes in somatic cells of mammalian females. A few genes are known to escape XCI and the mechanism for this escape remains unclear. Here, using mouse trophoblast stem (TS) cells, we address whether particular chromosomal interactions facilitate escape from imprinted XCI. We demonstrate that promoters of genes escaping XCI do not congregate to any particular region of the genome in TS ce ...[more]