Ontology highlight
ABSTRACT:
SUBMITTER: Johnson CP
PROVIDER: S-EPMC406449 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Johnson C P CP Fujimoto I I Perrin-Tricaud C C Rutishauser U U Leckband D D
Proceedings of the National Academy of Sciences of the United States of America 20040426 18
The extracellular regions of adhesion proteins of the Ig superfamily comprise multiple, tandemly arranged domains. We used directforce measurements to investigate how this modular architecture contributes to the adhesive interactions of the neural cell adhesion molecule (NCAM), a representative of this protein class. The extracellular region of NCAM comprises five immunoglobulin and two fibronectin domains. Previous investigations generated different models for the mechanism of homophilic adhesi ...[more]