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Cysteine promoted C-terminal hydrazinolysis of native peptides and proteins.

ABSTRACT: Tagging the terminus: N?S acyl transfer in native peptides and proteins can be reliably intercepted with hydrazine. The method allows selective labeling and ligation, without recourse to the use of protein-splicing elements. NCL=native chemical ligation.

SUBMITTER: Adams AL 

PROVIDER: S-EPMC4065347 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Cysteine promoted C-terminal hydrazinolysis of native peptides and proteins.

Adams Anna L AL   Cowper Ben B   Morgan Rachel E RE   Premdjee Bhavesh B   Caddick Stephen S   Macmillan Derek D  

Angewandte Chemie (International ed. in English) 20131009 49

Tagging the terminus: N→S acyl transfer in native peptides and proteins can be reliably intercepted with hydrazine. The method allows selective labeling and ligation, without recourse to the use of protein-splicing elements. NCL=native chemical ligation. ...[more]

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