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Late-stage modification of peptides and proteins at cysteine with diaryliodonium salts† † Electronic supplementary information (ESI) available. See DOI: 10.1039/d1sc03127a

ABSTRACT: The modification of peptides and proteins has emerged as a powerful means to efficiently prepare high value bioconjugates for a range of applications in chemical biology and for the development of next-generation therapeutics. Herein, we report a novel method for the chemoselective late-stage modification of peptides and proteins at cysteine in aqueous buffer with suitably functionalised diaryliodonium salts, furnishing stable thioether-linked synthetic conjugates. The power of this new platform is showcased through the late-stage modification of the affibody zEGFR and the histone protein H2A. New operationally simple platform for the chemoselective arylation of cysteine in peptides and proteins to access a variety of high value bioconjugates.

SUBMITTER: Byrne S

PROVIDER: S-EPMC8565360 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Late-stage modification of peptides and proteins at cysteine with diaryliodonium salts

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