Ontology highlight
ABSTRACT:
SUBMITTER: Xiao C
PROVIDER: S-EPMC4066342 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Xiao Changting C Dash Satya S Morgantini Cecilia C Patterson Bruce W BW Lewis Gary F GF
Diabetes 20140228 7
The dipeptidyl peptidase-4 inhibitor sitagliptin, an antidiabetic agent, which lowers blood glucose levels, also reduces postprandial lipid excursion after a mixed meal. The underlying mechanism of this effect, however, is not clear. This study examined the production and clearance of triglyceride-rich lipoprotein particles from the liver and intestine in healthy volunteers in response to a single oral dose of sitagliptin. Using stable isotope tracer techniques and with control of pancreatic hor ...[more]