Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC4066767 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Wang Wei W Naiyer Nada N Mitra Mithun M Li Jialin J Williams Mark C MC Rouzina Ioulia I Gorelick Robert J RJ Wu Zhengrong Z Musier-Forsyth Karin K
Nucleic acids research 20140509 11
During human immunodeficiency virus type 1 (HIV-1) maturation, three different forms of nucleocapsid (NC) protein-NCp15 (p9 + p6), NCp9 (p7 + SP2) and NCp7-appear successively. A mutant virus expressing NCp15 shows greatly reduced infectivity. Mature NCp7 is a chaperone protein that facilitates remodeling of nucleic acids (NAs) during reverse transcription. To understand the strict requirement for NCp15 processing, we compared the chaperone function of the three forms of NC. NCp15 anneals tRNA t ...[more]