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Aggregate risk score based on markers of inflammation, cell stress, and coagulation is an independent predictor of adverse cardiovascular outcomes.


ABSTRACT: This study sought to determine an aggregate, pathway-specific risk score for enhanced prediction of death and myocardial infarction (MI).Activation of inflammatory, coagulation, and cellular stress pathways contribute to atherosclerotic plaque rupture. We hypothesized that an aggregate risk score comprised of biomarkers involved in these different pathways-high-sensitivity C-reactive protein (CRP), fibrin degradation products (FDP), and heat shock protein 70 (HSP70) levels-would be a powerful predictor of death and MI.Serum levels of CRP, FDP, and HSP70 were measured in 3,415 consecutive patients with suspected or confirmed coronary artery disease (CAD) undergoing cardiac catheterization. Survival analyses were performed with models adjusted for established risk factors.Median follow-up was 2.3 years. Hazard ratios (HRs) for all-cause death and MI based on cutpoints were as follows: CRP ?3.0 mg/l, HR: 1.61; HSP70 >0.625 ng/ml, HR; 2.26; and FDP ?1.0 ?g/ml, HR: 1.62 (p < 0.0001 for all). An aggregate biomarker score between 0 and 3 was calculated based on these cutpoints. Compared with the group with a 0 score, HRs for all-cause death and MI were 1.83, 3.46, and 4.99 for those with scores of 1, 2, and 3, respectively (p for each: <0.001). Annual event rates were 16.3% for the 4.2% of patients with a score of 3 compared with 2.4% in 36.4% of patients with a score of 0. The C statistic and net reclassification improved (p < 0.0001) with the addition of the biomarker score.An aggregate score based on serum levels of CRP, FDP, and HSP70 is a predictor of future risk of death and MI in patients with suspected or known CAD.

SUBMITTER: Eapen DJ 

PROVIDER: S-EPMC4066955 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Aggregate risk score based on markers of inflammation, cell stress, and coagulation is an independent predictor of adverse cardiovascular outcomes.

Eapen Danny J DJ   Manocha Pankaj P   Patel Riyaz S RS   Hammadah Muhammad M   Veledar Emir E   Wassel Christina C   Nanjundappa Ravi A RA   Sikora Sergey S   Malayter Dylan D   Wilson Peter W F PW   Sperling Laurence L   Quyyumi Arshed A AA   Epstein Stephen E SE  

Journal of the American College of Cardiology 20130509 4


<h4>Objectives</h4>This study sought to determine an aggregate, pathway-specific risk score for enhanced prediction of death and myocardial infarction (MI).<h4>Background</h4>Activation of inflammatory, coagulation, and cellular stress pathways contribute to atherosclerotic plaque rupture. We hypothesized that an aggregate risk score comprised of biomarkers involved in these different pathways-high-sensitivity C-reactive protein (CRP), fibrin degradation products (FDP), and heat shock protein 70  ...[more]

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