Ontology highlight
ABSTRACT:
SUBMITTER: Yang CH
PROVIDER: S-EPMC4067285 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Yang Chun-Hung CH Wang Hui-Ling HL Lin Yi-Sheng YS Kumar K P Shravan KP Lin Hung-Chi HC Chang Chih-Jung CJ Lu Chia-Chen CC Huang Tsung-Teng TT Martel Jan J Ojcius David M DM Chang Yu-Sun YS Young John D JD Lai Hsin-Chih HC
PloS one 20140623 6
Cancer stem cells (CSCs) represent a unique sub-population of tumor cells with the ability to initiate tumor growth and sustain self-renewal. Although CSC biomarkers have been described for various tumors, only a few markers have been identified for nasopharyngeal carcinoma (NPC). In this study, we show that CD24+ cells isolated from human NPC cell lines express stem cell genes (Sox2, Oct4, Nanog, Bmi-1, and Rex-1), and show activation of the Wnt/β-catenin signaling pathway. CD24+ cells possess ...[more]