Ontology highlight
ABSTRACT:
SUBMITTER: Kawai T
PROVIDER: S-EPMC4960550 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Kawai Takayuki T Yasuchika Kentaro K Ishii Takamichi T Miyauchi Yuya Y Kojima Hidenobu H Yamaoka Ryoya R Katayama Hokahiro H Yoshitoshi Elena Yukie EY Ogiso Satoshi S Kita Sadahiko S Yasuda Katsutaro K Fukumitsu Ken K Komori Junji J Hatano Etsuro E Kawaguchi Yoshiya Y Uemoto Shinji S
Scientific reports 20160726
The current lack of cancer stem cell (CSC) markers that are easily evaluated by blood samples prevents the establishment of new therapeutic strategies in hepatocellular carcinoma (HCC). Herein, we examined whether sex determining region Y-box 9 (SOX9) represents a new CSC marker, and whether osteopontin (OPN) can be used as a surrogate marker of SOX9 in HCC. In HCC cell lines transfected with a SOX9 promoter-driven enhanced green fluorescence protein gene, FACS-isolated SOX9(+) cells were capabl ...[more]