Ontology highlight
ABSTRACT:
SUBMITTER: John A
PROVIDER: S-EPMC4067532 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
John Anita A Brylka Heike H Wiegreffe Christoph C Simon Ruth R Liu Pentao P Jüttner René R Crenshaw E Bryan EB Luyten Frank P FP Jenkins Nancy A NA Copeland Neal G NG Birchmeier Carmen C Britsch Stefan S
Development (Cambridge, England) 20120404 10
Dorsal spinal cord neurons receive and integrate somatosensory information provided by neurons located in dorsal root ganglia. Here we demonstrate that dorsal spinal neurons require the Krüppel-C(2)H(2) zinc-finger transcription factor Bcl11a for terminal differentiation and morphogenesis. The disrupted differentiation of dorsal spinal neurons observed in Bcl11a mutant mice interferes with their correct innervation by cutaneous sensory neurons. To understand the mechanism underlying the innervat ...[more]