Ontology highlight
ABSTRACT:
SUBMITTER: Ewan EE
PROVIDER: S-EPMC7801468 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Ewan Eric E EE Avraham Oshri O Carlin Dan D Gonçalves Tassia Mangetti TM Zhao Guoyan G Cavalli Valeria V
Scientific reports 20210111 1
Regeneration failure after spinal cord injury (SCI) results in part from the lack of a pro-regenerative response in injured neurons, but the response to SCI has not been examined specifically in injured sensory neurons. Using RNA sequencing of dorsal root ganglion, we determined that thoracic SCI elicits a transcriptional response distinct from sciatic nerve injury (SNI). Both SNI and SCI induced upregulation of ATF3 and Jun, yet this response failed to promote growth in sensory neurons after SC ...[more]