Ontology highlight
ABSTRACT: Background
The study of non-atopic asthma/wheeze in children separately from atopic asthma is relatively recent. Studies have focused on single risk factors and had inconsistent findings.Objective
To review evidence on factors associated with non-atopic asthma/wheeze in children and adolescents.Methods
A review of studies of risk factors for non-atopic asthma/wheeze which had a non-asthmatic comparison group, and assessed atopy by skin-prick test or allergen-specific IgE.Results
Studies of non-atopic asthma/wheeze used a wide diversity of definitions of asthma/wheeze, comparison groups and methods to assess atopy. Among 30 risk factors evaluated in the 43 studies only 3 (family history of asthma/rhinitis/eczema, dampness/mold in the household, and lower respiratory tract infections in childhood) showed consistent associations with non-atopic asthma/wheeze. No or limited period of breastfeeding was less consistently associated with non-atopic asthma/wheeze. The few studies examining the effects of overweight/obesity and psychological/social factors showed consistent associations. We used a novel graphical presentation of different risk factors for non-atopic asthma/wheeze, allowing a more complete perception of the complex pattern of effects.Conclusions
More research using standardized methodology is needed on the causes of non-atopic asthma.
SUBMITTER: Strina A
PROVIDER: S-EPMC4068161 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Emerging themes in epidemiology 20140606
<h4>Background</h4>The study of non-atopic asthma/wheeze in children separately from atopic asthma is relatively recent. Studies have focused on single risk factors and had inconsistent findings.<h4>Objective</h4>To review evidence on factors associated with non-atopic asthma/wheeze in children and adolescents.<h4>Methods</h4>A review of studies of risk factors for non-atopic asthma/wheeze which had a non-asthmatic comparison group, and assessed atopy by skin-prick test or allergen-specific IgE. ...[more]