Ontology highlight
ABSTRACT:
SUBMITTER: Collins C
PROVIDER: S-EPMC4068264 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Collins Caitlin C Osborne Lukas D LD Guilluy Christophe C Chen Zhongming Z O'Brien E Tim ET Reader John S JS Burridge Keith K Superfine Richard R Tzima Ellie E
Nature communications 20140611
Endothelial cells (ECs) lining blood vessels express many mechanosensors, including platelet endothelial cell adhesion molecule-1 (PECAM-1), that convert mechanical force into biochemical signals. While it is accepted that mechanical stresses and the mechanical properties of ECs regulate vessel health, the relationship between force and biological response remains elusive. Here we show that ECs integrate mechanical forces and extracellular matrix (ECM) cues to modulate their own mechanical prope ...[more]