Ontology highlight
ABSTRACT:
SUBMITTER: Chen DY
PROVIDER: S-EPMC6659696 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Chen Dong-Yuan DY Crest Justin J Streichan Sebastian J SJ Bilder David D
Nature communications 20190726 1
Organs are sculpted by extracellular as well as cell-intrinsic forces, but how collective cell dynamics are orchestrated in response to environmental cues is poorly understood. Here we apply advanced image analysis to reveal extracellular matrix-responsive cell behaviors that drive elongation of the Drosophila follicle, a model system in which basement membrane stiffness instructs three-dimensional tissue morphogenesis. Through in toto morphometric analyses of wild type and round egg mutants, we ...[more]