Mechanism and regulation of incisions during DNA interstrand cross-link repair.
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ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC4076290 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
Mechanism and regulation of incisions during DNA interstrand cross-link repair.
Zhang Jieqiong J Walter Johannes C JC
DNA repair 20140424
A critical step in DNA interstrand cross-link repair is the programmed collapse of replication forks that have stalled at an ICL. This event is regulated by the Fanconi anemia pathway, which suppresses bone marrow failure and cancer. In this perspective, we focus on the structure of forks that have stalled at ICLs, how these structures might be incised by endonucleases, and how incision is regulated by the Fanconi anemia pathway. ...[more]
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