Ontology highlight
ABSTRACT:
SUBMITTER: De Araujo JS
PROVIDER: S-EPMC4068551 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
De Araújo J S JS Da Silva C F CF Batista D G J DG Da Silva P B PB Meuser M B MB Aiub C A F CA da Silva M F V MF Araújo-Lima C F CF Banerjee M M Farahat A A AA Stephens C E CE Kumar A A Boykin D W DW Soeiro M N C MN
Antimicrobial agents and chemotherapy 20140303 7
Fifteen novel arylimidamides (AIAs) (6 bis-amidino and 9 mono-amidino analogues) were assayed against Trypanosoma cruzi in vitro and in vivo. All the bis-AIAs were more effective than the mono-AIAs, and two analogues, DB1967 and DB1989, were further evaluated in vivo. Although both of them reduced parasitemia, protection against mortality was not achieved. Our results show that the number of amidino-terminal units affects the efficacy of arylimidamides against T. cruzi. ...[more]