Inhibition of aminoglycoside 6'-N-acetyltransferase type Ib by zinc: reversal of amikacin resistance in Acinetobacter baumannii and Escherichia coli by a zinc ionophore.
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ABSTRACT:
SUBMITTER: Lin DL
PROVIDER: S-EPMC4068593 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
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Inhibition of aminoglycoside 6'-N-acetyltransferase type Ib by zinc: reversal of amikacin resistance in Acinetobacter baumannii and Escherichia coli by a zinc ionophore.
Lin David L DL Tran Tung T Alam Jamal Y JY Herron Steven R SR Ramirez Maria Soledad MS Tolmasky Marcelo E ME
Antimicrobial agents and chemotherapy 20140512 7
In vitro activity of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] was inhibited by ZnCl2 with a 50% inhibitory concentration (IC50) of 15 μM. Growth of Acinetobacter baumannii or Escherichia coli harboring aac(6')-Ib in cultures containing 8 μg/ml amikacin was significantly inhibited by the addition of 2 μM Zn(2+) in complex with the ionophore pyrithione (ZnPT). ...[more]
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