Ontology highlight
ABSTRACT:
SUBMITTER: Keramati AR
PROVIDER: S-EPMC4069260 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Keramati Ali R AR Fathzadeh Mohsen M Go Gwang-Woong GW Singh Rajvir R Choi Murim M Faramarzi Saeed S Mane Shrikant S Kasaei Mohammad M Sarajzadeh-Fard Kazem K Hwa John J Kidd Kenneth K KK Babaee Bigi Mohammad A MA Malekzadeh Reza R Hosseinian Adallat A Babaei Masoud M Lifton Richard P RP Mani Arya A
The New England journal of medicine 20140501 20
<h4>Background</h4>Genetic analysis has been successful in identifying causative mutations for individual cardiovascular risk factors. Success has been more limited in mapping susceptibility genes for clusters of cardiovascular risk traits, such as those in the metabolic syndrome.<h4>Methods</h4>We identified three large families with coinheritance of early-onset coronary artery disease, central obesity, hypertension, and diabetes. We used linkage analysis and whole-exome sequencing to identify ...[more]