Cardiometabolic Proteins Associated with Metabolic Syndrome.
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ABSTRACT:
SUBMITTER: Lind L
PROVIDER: S-EPMC6588107 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
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Cardiometabolic Proteins Associated with Metabolic Syndrome.
Lind Lars L Elmståhl Sölve S Ingelsson Erik E
Metabolic syndrome and related disorders 20190318 5
<b><i>Background:</i></b> Although metabolic syndrome (MetS) was described in the late 80s, the molecular mechanisms underlying clustering of risk factors in certain individuals are not fully understood. The present study used targeted proteomics to establish cardiometabolic proteins related to all MetS components, thereby providing new hypotheses regarding pathways involved in the pathogenesis of MetS. <b><i>Methods:</i></b> In the EpiHealth study, 249 cardiometabolic proteins were measured by ...[more]
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| S-EPMC4766694 | biostudies-literature
Project description:OBJECTIVE: To study the association between metabolic syndrome (MetS) and self-perceived depression. DESIGN: A cross-sectional community-based study. SETTING: Semi-rural community of Lapinlahti in eastern Finland in 2005. SUBJECTS: A total of 416 subjects in eight adult birth cohorts (55%) with complete Beck Depression Inventory (BDI-21) questionnaire data. MAIN OUTCOME MEASURES: The values of the 21 BDI items and the BDI-21 total score with a cut-off point of 14/15 were used to study the association between MetS and depression. National Cholesterol Education Programme (NCEP) 2005 criteria were used for MetS classification. RESULTS: The total BDI-21 score was significantly higher in the subjects with MetS than in the subjects without MetS (p=0.020). Men with MetS were significantly worse off than men without MetS in the BDI-21 items of irritability (p=0.008), work inhibition (p=0.008), fatigability (p=0.037), weight loss (p=0.045), and loss of libido (p=0.014), while women were only so on the item of loss of libido (p=0.007). In a logistic regression analysis using a BDI-21 cut-off point of 14/15 adjusted for age, marital status, vocational education, and working status, significant association was retained between perceived depression and elevated blood glucose among men (OR=1.697) and large waist circumference among women (OR=1.066). CONCLUSION: Elevated plasma glucose in men and central obesity in women are associated with self-perceived depression. This co-occurrence deserves attention in clinical practice.
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