Heterologous expression and manipulation of three tetracycline biosynthetic pathways.
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ABSTRACT:
SUBMITTER: Wang P
PROVIDER: S-EPMC4070387 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Publications
Heterologous expression and manipulation of three tetracycline biosynthetic pathways.
Wang Peng P Kim Woncheol W Pickens Lauren B LB Gao Xue X Tang Yi Y
Angewandte Chemie (International ed. in English) 20120928 44
A very accommodating host: Three tetracycline biosynthetic pathways were overexpressed and manipulated in the heterologous host Streptomyces lividans K4-114. Through the inactivation of various genes and characterization of the resulting biosynthetic intermediates, new tetracycline-modifying enzymes were identified (see scheme). ...[more]
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