Dataset Information

Association between RANTES gene polymorphisms and asthma: a meta-analysis.

ABSTRACT:

Background

A few recent studies have suggested that regulated on activation, normal T cell expressed and secreted (RANTES) polymorphisms (-403 G/A, -28C/G) are associated with asthma. However, there still existed studies which did not confirm these correlations.

Objective

The objective of this study was to evaluate the relationship of RANTES and asthma using a meta-analysis.

Methods

Pubmed, Embase, and Cochrane library databases were systemically searched. Data were extracted by two independent reviewers and pooled odds ratio (OR) with 95% confidence interval (CI) were calculated.

Results

Eighteen studies were enrolled, including a total of 2558 cases and 2630 controls of -403 G/A, as well as 3311 cases and 4031 controls of -28C/G in this meta-analysis. The overall ORs and 95% CIs of -403 G/A were 1.19, 1.06-1.33 (P<0.001) and 1.25, 1.03-1.51 (P?=?0.933) in dominant and recessive models, respectively. The overall ORs and 95% CIs of -28G were 1.23, 1.09-1.39 (P?=?0.221) and 1.76, 1.32-2.34 (P?=?0.356) in dominant and recessive models, respectively. No publication bias among studies was showed.

Conclusions

This meta-analysis showed that RANTES -403 G/A polymorphism was a risk factor for asthma, while -28C/G polymorphism were not associated with asthma.

SUBMITTER: Wen D

PROVIDER: S-EPMC4070887 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association between RANTES gene polymorphisms and asthma: a meta-analysis.

Wen Dan D Du Xin X Nie Shao-Ping SP Dong Jian-Zeng JZ Ma Chang-Sheng CS

PloS one 20140625 6

<h4>Background</h4>A few recent studies have suggested that regulated on activation, normal T cell expressed and secreted (RANTES) polymorphisms (-403 G/A, -28C/G) are associated with asthma. However, there still existed studies which did not confirm these correlations.<h4>Objective</h4>The objective of this study was to evaluate the relationship of RANTES and asthma using a meta-analysis.<h4>Methods</h4>Pubmed, Embase, and Cochrane library databases were systemically searched. Data were extract ...[more]

PMID: 24963658

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Dataset Information

Association between RANTES gene polymorphisms and asthma: a meta-analysis.

Background

Objective

Methods

Results

Conclusions

Publications

Association between RANTES gene polymorphisms and asthma: a meta-analysis.

Similar Datasets

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