Ontology highlight
ABSTRACT:
SUBMITTER: Brunet I
PROVIDER: S-EPMC4071369 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20140617 7
Autonomic sympathetic nerves innervate peripheral resistance arteries, thereby regulating vascular tone and controlling blood supply to organs. Despite the fundamental importance of blood flow control, how sympathetic arterial innervation develops remains largely unknown. Here, we identified the axon guidance cue netrin-1 as an essential factor required for development of arterial innervation in mice. Netrin-1 was produced by arterial smooth muscle cells (SMCs) at the onset of innervation, and a ...[more]