Ontology highlight
ABSTRACT:
SUBMITTER: Ryu YK
PROVIDER: S-EPMC3774606 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Developmental biology 20130227 1
During nervous system development, axon branching at nerve terminals is an essential step in the formation of functional connections between neurons and target cells. It is known that target tissues exert control of terminal arborization through secretion of trophic factors. However, whether the in-growing axons themselves produce diffusible cues to instruct target innervation remains unclear. Here, we use conditional mutant mice to show that Wnt5a derived from sympathetic neurons is required fo ...[more]