Ontology highlight
ABSTRACT:
SUBMITTER: Dell'Anno MT
PROVIDER: S-EPMC4071410 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Dell'Anno Maria Teresa MT Caiazzo Massimiliano M Leo Damiana D Dvoretskova Elena E Medrihan Lucian L Colasante Gaia G Giannelli Serena S Theka Ilda I Russo Giovanni G Mus Liudmila L Pezzoli Gianni G Gainetdinov Raul R RR Benfenati Fabio F Taverna Stefano S Dityatev Alexander A Broccoli Vania V
The Journal of clinical investigation 20140617 7
Direct lineage reprogramming through genetic-based strategies enables the conversion of differentiated somatic cells into functional neurons and distinct neuronal subtypes. Induced dopaminergic (iDA) neurons can be generated by direct conversion of skin fibroblasts; however, their in vivo phenotypic and functional properties remain incompletely understood, leaving their impact on Parkinson's disease (PD) cell therapy and modeling uncertain. Here, we determined that iDA neurons retain a transgene ...[more]