Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Fuhrmann M
PROVIDER: S-EPMC4072212 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease.
Fuhrmann Martin M Bittner Tobias T Jung Christian K E CK Burgold Steffen S Page Richard M RM Mitteregger Gerda G Haass Christian C LaFerla Frank M FM Kretzschmar Hans H Herms Jochen J
Nature neuroscience 20100321 4
Microglia, the immune cells of the brain, can have a beneficial effect in Alzheimer's disease by phagocytosing amyloid-beta. Two-photon in vivo imaging of neuron loss in the intact brain of living Alzheimer's disease mice revealed an involvement of microglia in neuron elimination, indicated by locally increased number and migration velocity of microglia around lost neurons. Knockout of the microglial chemokine receptor Cx3cr1, which is critical in neuron-microglia communication, prevented neuron ...[more]
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