Ontology highlight
ABSTRACT:
SUBMITTER: Laflamme N
PROVIDER: S-EPMC6037698 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Laflamme Nathalie N Cisbani Giulia G Préfontaine Paul P Srour Younes Y Bernier Jordan J St-Pierre Marie-Kim MK Tremblay Marie-Ève MÈ Rivest Serge S
Frontiers in cellular neuroscience 20180703
A pathological hallmark of multiple sclerosis (MS) is myelin loss in brain white matter accompanied by compromised remyelination. Demyelinated lesions are deeply associated with oligodendrocyte apoptosis and a robust inflammatory response. Although various studies point towards a noxious role of inflammation in MS, others emphasize a positive role for the innate immune cells in disease progression. A cytokine well-known to stimulate cell survival, proliferation and differentiation of myeloid cel ...[more]