Ontology highlight
ABSTRACT:
SUBMITTER: Walters RD
PROVIDER: S-EPMC4072727 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
PloS one 20140626 6
The AP-1 family of transcriptional activators plays pivotal roles in regulating a wide range of biological processes from the immune response to tumorigenesis. Determining the roles of specific AP-1 dimers in cells, however, has remained challenging because common molecular biology techniques are unable to distinguish between the role of, for example, cJun/cJun homodimers versus cJun/cFos heterodimers. Here we used SELEX (systematic evolution of ligands by exponential enrichment) to identify and ...[more]