Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC4073211 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Zhang Liwei L Chen Lee H LH Wan Hong H Yang Rui R Wang Zhaohui Z Feng Jie J Yang Shaohua S Jones Siân S Wang Sizhen S Zhou Weixin W Zhu Huishan H Killela Patrick J PJ Zhang Junting J Wu Zhen Z Li Guilin G Hao Shuyu S Wang Yu Y Webb Joseph B JB Friedman Henry S HS Friedman Allan H AH McLendon Roger E RE He Yiping Y Reitman Zachary J ZJ Bigner Darell D DD Yan Hai H
Nature genetics 20140601 7
Gliomas arising in the brainstem and thalamus are devastating tumors that are difficult to surgically resect. To determine the genetic and epigenetic landscape of these tumors, we performed exomic sequencing of 14 brainstem gliomas (BSGs) and 12 thalamic gliomas. We also performed targeted mutational analysis of an additional 24 such tumors and genome-wide methylation profiling of 45 gliomas. This study led to the discovery of tumor-specific mutations in PPM1D, encoding wild-type p53-induced pro ...[more]